Endocrine Abstracts

Introduction: Duchenne muscular dystrophy (DMD) is a genetic condition caused by mutations in the X-linked dystrophin-gene leading to muscle degeneration and early death in males.Since DMD is characterized by aggressive inflammation it is recommended the use of pharmacological treatment with corticosteroids (CS). Type-1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood and is caused by insulin deficiency resulting from the autoimmune destruction ...

Background: Using new technologies, such as glucose sensors and insulin pumps, may help patients with type 1 diabetes mellitus achieve better glycemic control and quality of life. With the occasion of implementing the National Program for free distribution of continuous glucose monitoring systems (CGMS) starting with January 2019, children aged under 13 years were investigated in order to assess the association between previous use of CGMS and insulin pumps and the metabolic c...

Background: Type 1 diabetes is a chronic disease requiring constant management and a disciplined lifestyle, especially in children. Real-time continuous glucose monitoring system (RT-CGMS) can be a useful tool in maintaining good glycemic control. In our medical centre, beginning with January 2019, a National Program for free distribution of RT-CGMS has been set in motion. The results from one of our previous studies indicated a significant increase in glycosylated haemoglobin...

Aim: To test the hypothesis that exposure to insulin glargine might be associated with increased risk of cancer mortality compared with human basal insulin preparations.Materials and methods: All consecutive diabetes patients aged over 40 years, residing in a major urban area were screened at their first diabetes outpatient visit between 01/01/2001 and 12/31/2008 (n=79 869). Exclusion criteria were insulin treatment at screening (n=14 7...

Introduction: Patients with non-functioning pituitary adenomas (NFPA) and hipopituitarism had a reduced life expectancy.Aims: To assess mortality ratio and to identify prognostic factors associated with mortality in patients with NFPA in the last decade.Methods: A 196 patients (83 F/113 M, mean age 52.7±0.9 years) with NFPA admitted in a single Neuroendocrinology Department between January 2001 and December 2010 were retrospec...

Introduction: Hybrid closed loop (HCL) systems are made up of continuous glucose monitoring (CGM) sensor, an algorithm that receives the readings from the CGM and an insulin pump able to deliver variable insulin doses according to the information received from the other two parts. Predictive low-glucose suspend (PLGS) insulin pump is able to stop the administration of insulin before hypoglycemia occurs. These new technologies are meant to improve the quality of life and help t...

Introduction: Patients with untreated acromegaly have a reduced survival, mostly due to vascular disease. Recent studies claim an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with reduced survival in acromegaly.Methods: Three hundred and twenty-seven patients (207 F/110 M, mean age 48.1±0.7 years, (range 18–81.42)) with acromegaly admitted in a sin...

Background: Real-Time Continuous Glucose Monitoring Systems (RT-CGMS) represent a minimally invasive method for frequent glucose monitoring, allowing a better glycemic control for patients with type 1 diabetes. With the occasion of implementing the National Program for free access to RT-CGMS, we assessed the 6 months impact of RT-CGMS on the metabolic control, evaluated by glycated haemoglobin (HbA1c).Methods: In this unicentric, prospective cohort study...